Association of NPPB rs198389 and NPPA rs5068 single-nucleotide polymorphisms with natriuretic peptide levels and heart failure progression risks in patients with atrial fibrillation

Natriuretic peptides (NUPs) are the strongest predictors of poor prognosis in patients with heart failure (HF). Single-nucleotide polymorphisms (SNPs) rs198389 NPPB gene and rs5068 NPPA associated altered levels NUP. The role candidate activity NUP system association NPPA/ SNPs risk cardiovascular disease (CVD) individuals HF atrial fibrillation (AF) is not well understood. study aims to evaluate allele genotype frequencies a selective sample Belarusian population, determine relationship these concentrations, assess prognostic significance on hospitalization permanent AF. involved 187 patients. main group included 152 left ventricular ejection fraction (LVEF) < 50 %. Group 1 48 AF; 2 – 51 sinus rhythm (SR) 35 control group. brain natriuretic (ANP BNP) N-terminal fragment peptide (NT-proBNP) were determined. A genetic testing polymorphic loci was performed. primary endpoint due progression. average observation period 12.1 [from 9 14] months. distribution LVEF % comparable that without CVD. In persistent AF, minor C higher BNP compared SR (542 [333.7; 909.4] pg/ml versus 247.3 [244; 365.2] pg/ml; p 0.05), but it has no NT-proBNP level. ANP NPPA. frequency T hospitalized significantly lower who (22 (44 %) 83 (62 %); = 0.04). presence progression odds ratio (OR) 2.071 [95 CI from 1.072 4.001], 0.05.